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Review Article| Volume 40, ISSUE 3, P371-382, July 2013

Patient Selection in Outpatient Surgery

      Keywords

      Key points

      • Ambulatory surgery is commonplace for a multitude of procedures and a wide range of patients.
      • The types of procedures performed in the ambulatory setting are becoming more work-intensive, and patients with comorbidities make for a challenging environment.
      • For a safe environment for surgery in ambulatory facilities, the complex task of patient selection is necessary.
      • Until an algorithm is created that includes provider, procedure, facility, and patient comorbidities, clinicians rely on general guidlines rather than precise recommendations.
      • When determining if a patient is suitable for ambulatory surgery, multiple factors must be assessed.
      Ambulatory surgical volume in the United States increased 300% between 1992 and 2006.

      MEDPAC Report to the Congress: Medicare Payment Policy. 2004.

      • Cullen K.A.
      • Hall M.J.
      • Golosinskiy A.
      Ambulatory surgery in the United States, 2006.
      In 2006, an estimated 53.3 million procedures were performed in ambulatory centers, 19.9 million in hospitals, and 14.9 million in freestanding surgical centers.
      • Cullen K.A.
      • Hall M.J.
      • Golosinskiy A.
      Ambulatory surgery in the United States, 2006.
      The increase has occurred partly because of financial incentives, changes in clinical practice from advances in technology, and patient expectations. Whether a case is appropriate for the ambulatory setting depends on where the surgery will occur, the personnel involved, the surgical procedure, and the patient’s medical status. Consideration of these 4 criteria will help achieve optimal patient outcomes.
      Ambulatory surgery can occur in a physician’s office, freestanding ambulatory surgical center, building on a medical campus, or hospital. In the hospital setting, ambulatory procedures can be consolidated in one location or interspersed with inpatient procedures. Transportation between the procedural facility and a hospital for additional postoperative care also must be considered, and a transfer process should be in place. A facility that is accredited by the American Association for Accreditation of Ambulatory Surgery Facilities, the Accreditation Association for Ambulatory Health Care, or the Joint Commission is essentially obliged to operate in a manner consistent with the American Society of Anesthesiologists (ASA) standards and guidelines. In addition to the physical plant, the available equipment and supplies will also influence what procedures may be performed. The ASA and others have set expectations for ambulatory anesthesia in the form of standards and guidelines that apply independent of location.

      Guidelines for ambulatory anesthesia and surgery. American Society of Anesthesiologists Web site. Available at: http://www.asahq.org/For-Healthcare-Professionals/Standards-Guidelines-and-Statements.aspx. Accessed August 31, 2012.

      For example, the ASA and the Agency for Healthcare Research Quality recommend that equipment for standard monitoring include a noninvasive blood pressure monitor, a means to record heart rate and respiration, an electrocardiograph, and a pulse oximeter.

      Evidence-based patient safety advisory: patient selection and procedures in ambulatory surgery. Agency for Healthcare Research and Quality Web site. Available at: http://guidelines.gov/content.aspx?id=15334. Accessed September 1, 2012.

      The ASA adds continuous monitoring of end expiratory carbon dioxide and the ability to measure temperature, if indicated.

      Standards for basic anesthetic monitoring. American Society of Anesthesiologists Web site. Available at: http://www.asahq.org/For-Healthcare-Professionals/Standards-Guidelines-and-Statements.aspx. Accessed September 10, 2012.

      Safety is a continuum from the preoperative to the postoperative phase of care; at the time of discharge, patients should received written postoperative instructions and be discharged to the care of a responsible adult. Ideally, when surgery is performed in a freestanding ambulatory surgery center or office, the surgeon performing the surgery should have credentials to perform that procedure in a hospital and should be operating within the scope of his specialty training.
      Another consideration is the personnel staffing the center. Will anesthesia be required, and if so, how much and administered by whom? Will a registered nurse be sufficient if anesthesia is given as a local injection with moderate sedation, or will the services of an anesthesiologist or a certified registered nurse anesthetist (CRNA) be needed? One study showed that anesthesia provided by nonanesthesiologists was associated with significantly higher rates of unexpected hospital admissions compared with that provided by solo anesthesiologists or a care team of physician and CRNA.
      • Memtsoudis S.G.
      • Ma Y.
      • Swamidoss C.P.
      • et al.
      Factors influencing unexpected disposition after orthopedic ambulatory surgery.
      Who will perform the procedure? Will it be a physician, physician’s assistant, or CRNA who may require physician supervision? Do the recovery room personnel have postanesthesia care experience commensurate with the type of anesthesia anticipated? Will they be able to handle possible complications from the procedure or the anesthetic? In summary, the staffing for all procedures should be adequate to meet the needs of the patient and the providers.

      Guidelines for ambulatory anesthesia and surgery. American Society of Anesthesiologists Web site. Available at: http://www.asahq.org/For-Healthcare-Professionals/Standards-Guidelines-and-Statements.aspx. Accessed August 31, 2012.

      Initially, ambulatory procedures were restricted to those associated with minimal blood loss that could be performed in less than 90 minutes with simple equipment, requiring minimal postoperative care and producing only mild pain that could be controlled with oral medications.
      • White P.F.
      Outpatient anesthesia.
      Now the only criterion strictly applied is that the patient is able to go home the same day of the procedure, although for some patients a 23-hour hospital stay or other nursing care environment is necessary.
      The most complex variable is the patient, whose comorbidities determine whether a procedure may be performed in an ambulatory facility. In 1940, a classification scheme was created to standardize and define the operative risk of patients based on the history and physical examination.
      • Schwam S.J.
      • Gold M.I.
      • Craythorne N.W.
      The ASA physical status classification: a revision.
      Over the past 70 years, this original classification has been modified, with the current ASA physical status (PS) classification divided into 6 categories (Box 1). Although the ASA classification was not created originally as a predictive index of perioperative risk, it has been used as a proxy for risk in several studies.
      • Voney G.
      • Biro P.
      • Roos M.
      • et al.
      Interrelation of peri-operative morbidity and ASA class assignment in patients undergoing gynaecological surgery.
      • Davenport D.L.
      • Bowe E.A.
      • Henderson W.G.
      • et al.
      National Surgical Quality Improvement Program (NSQIP) risk factors can be used to validate American Society of Anesthesiologists Physical Status Classification (ASA PS) levels.
      Classification of a patient’s physical condition
      • 1.
        A normal healthy patient.
      • 2.
        A patient with mild systemic disease.
      • 3.
        A patient with severe systemic disease.
      • 4.
        A patient with severe systemic disease that is a constant threat to life.
      • 5.
        A moribund patient who is not expected to survive without the operation.
      • 6.
        A patient who has been declared brain-dead and whose organs are being removed for donor purposes.
      Overall surgical mortality for patients with ASA PS 1 through 3 is low (Table 1), but as PS class increases, so does the risk for morbidity. In a prospective analysis of 38,598 patients undergoing 45,090 ambulatory procedures, patients with ASA PS 3 constituted 24% of the morbidity.
      • Warner M.A.
      • Shields S.E.
      • Chute C.G.
      Major morbidity and mortality within 1 month of ambulatory surgery and anesthesia.
      In another study, an ASA PS rating of 2 or 3 predicted a 2-fold greater risk for unanticipated hospital admissions after ambulatory surgery.
      • Fortier J.
      • Chung F.
      • Su J.
      Unanticipated admission after ambulatory surgery—a prospective study.
      A retrospective study of 28,921 patients undergoing ambulatory surgery found no significant difference in unplanned admissions between those with ASA PS 3 and those with ASA PS 1 and 2, although those with ASA PS 3 experienced more pain than patients with ASA PS 1 and 2.
      • Ansell G.L.
      • Montgomery J.E.
      Outcome of ASA III patients undergoing day case surgery.
      Although patients with an ASA PS 1 through 3 have low risk with low rates (<2%) of postoperative complications,
      • Fortier J.
      • Chung F.
      • Su J.
      Unanticipated admission after ambulatory surgery—a prospective study.
      • Ansell G.L.
      • Montgomery J.E.
      Outcome of ASA III patients undergoing day case surgery.
      the overall medical condition of a patient is the most important consideration,
      • Verma R.
      • Alladi R.
      • Jackson I.
      • et al.
      Guidelines: day case and short stay surgery: 2.
      and ASA PS alone should not determine eligibility for ambulatory surgery.
      Table 1American Society of Anesthesiologists classification and 30-day surgical mortality
      Data from Davenport DL, Bowe EA, Henderson WG, et al. National Surgical Quality Improvement Program (NSQIP) risk factors can be used to validate American Society of Anesthesiologists Physical Status Classification (ASA PS) Levels. Ann Surg 2006;243:636–44.
      ASA Physical Status Level30-Day Mortality Rate (%)
      10.0 ± 0.0
      20.2 ± 0.1
      32.2 ± 0.4
      415.2 ± 2.4
      570.0 ± 10.5

      Cardiovascular disease

      The prevalence of coronary heart disease (CHD) in the United States is now 6%, with the greatest incidence in people 65 years of age or older (19.8%), followed by people aged 45 to 64 years (4.6%).
      • Centers for Disease Control and Prevention (CDC)
      Prevalence of coronary heart disease—United States 2006-2010.
      The overall mortality rates for patients with CHD have decreased since the 1960s, and this is attributable to improved medical treatment.
      • Xu J.Q.
      • Kochanek K.D.
      • Murphy S.L.
      • et al.
      Deaths: final data for 2007.
      In 2007, the American College of Cardiology (ACC) and the American Heart Association (AHA) published updated guidelines for cardiac evaluation and care for patients undergoing noncardiac surgery (Fig. 1).
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      For patients with unstable coronary syndromes, such as unstable or severe angina or recent myocardial infarction, decompensated heart failure, arrhythmias (high-grade or Mobitz II atrioventricular block, third-degree atrioventricular block, symptomatic ventricular arrhythmia, supraventricular arrhythmias with uncontrolled ventricular rate, symptomatic bradycardia, and newly recognized ventricular tachycardia), or severe valvular disease (severe aortic stenosis and symptomatic mitral stenosis), elective surgery should be delayed until further evaluation.
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      In a 1978 study of patients who had a myocardial infarction within 6 months before surgery, 27.3% experienced a perioperative infarction or cardiac death.
      • Goldman L.
      • Claldera D.L.
      • Soutwick F.S.
      • et al.
      Cardiac risk factors and complications in non-cardiac surgery.
      A 2012 study of the risk of perioperative myocardial infarction in 971,455 patients who had an infarction before surgery demonstrated that only 2% experienced a reinfarction.
      • Larsen K.D.
      • Rubinfeld I.S.
      Changing risk of perioperative myocardial infarction.
      Despite the apparent dramatic decrease in reinfarction, active cardiac symptoms do signal a risk.
      • Sweitzer B.J.
      Preoperative screening, evaluation, and optimization of the patient’s medical status before outpatient surgery.
      For some patients, ambulatory surgery may not be a low-risk procedure.
      Figure thumbnail gr1
      Fig. 1Cardiac evaluation and care algorithm for noncardiac surgery. Stepwise approach to preoperative cardiac assessment. *Subsequent care may include cancellation or delay of surgery, coronary revascularization followed by noncardiac surgery, or intensified care.
      (From Eagle KA, Berger PB, Calkins H, et al. ACC/AHA guideline update for perioperative cardiovascular evaluation for noncardiac surgery—executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1996 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery). J Am Coll Cardiol 2002;39(3):542–53. http://dx.doi.org/10.1016/S0735-1097(01)01788-0; with permission.)
      A patient’s functional status is the last criterion to be evaluated under the ACC/AHA algorithm. One metabolic equivalent (MET), the amount of oxygen consumed while sitting at rest, is equal to 3.5 mL of oxygen per kilogram of body weight per minute.
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      The threshold for good functional capacity is 4 METs (able to climb 1 flight of stairs or perform light housework). Patients who were not able to perform 4 METs during daily activities had increased perioperative and long-term risks, and an inverse relationship was seen between the number of blocks or flights a patient could walk and perioperative cardiovascular events.
      • Reilly D.F.
      • McNeely M.J.
      • Doerner D.
      • et al.
      Self –reported exercise tolerance and the risk of serious perioperative complications.
      If a patient does not have good functional capacity or is unable to perform 4 METs during daily activities, clinical predictors (eg, ischemic heart disease, heart failure, cerebrovascular disease, diabetes, renal insufficiency) and surgical risk will determine whether further perioperative testing is needed.
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      For patients with cardiac stents, the ACC, AHA, and the American College of Surgeons have developed joint advisory recommendations for dual antiplatelet therapy. Patients with a bare metal stent should be treated with clopidogrel, 75 mg, and aspirin, 325 mg, for a minimum of 1 month, a sirolimus drug-eluting stent (DES) for a minimum of 3 months, and a paclitaxel DES for a minimum of 6 to 12 months to prevent stent thrombosis.
      • Grines C.L.
      • Bonow R.O.
      • Case D.E.
      • et al.
      Antiplatelet therapy in patients with coronary artery stents. A science advisory from the American Heart Association, the American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians.
      In a large observational study in which antiplatelet therapy was discontinued prematurely for patients with a DES, 29% of patients developed stent thrombosis.
      • Iakovou I.
      • Schmidt T.
      • Bonizzoni E.
      • et al.
      Incidence, predictors and outcome of thrombosis after successful implantation of drug-eluting stents.
      Surgery is not recommended for at least 90 days after implantation of a bare metal stent. The odds ratio (OR) for a major cardiac event after surgery within 30 days of stent placement was 3.6, and was 1.6 for surgeries performed between 31 and 90 days of placement. For patients with DES implants, the rate of serious cardiac events was 5.7% to 6.6% for surgeries performed in fewer than 365 days from stent placement and 3.3% in surgeries after 365 days. A cardiologist should be consulted before discontinuation of antiplatelet therapy in these individuals. Patients who are on β-blocker therapy should continue these agents through the perioperative period.
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      The ACC/AHA guidelines provide the tools to determine whether additional cardiac testing is required before surgery, and following the guidelines for antiplatelet and medical therapy further decreases patient risk. Individuals at high risk for perioperative cardiac events and those with recent myocardial infarctions or cardiac interventions may not be suitable for procedures in an ambulatory setting without access to interventional cardiology.

      Pulmonary risk factors

      Asthma affects 24.6 million people in the United States, or approximately 8.2% of the population.
      • Akinbami L.
      • Moorman J.E.
      • Liu X.
      Asthma prevalence, health care use, and mortality: United States, 2005-2009.
      Chronic obstructive pulmonary disease (COPD) is identified in at least 10 million adults, and the Centers for Disease Control and Prevention (CDC) believes it is underdiagnosed.
      • Mannino D.M.
      • Homa D.M.
      • Akinbami L.J.
      • et al.
      Chronic obstructive pulmonary disease surveillance–United States, 1971-2000.
      Although postoperative pulmonary complications are as prevalent as perioperative cardiac complications,
      • Smetana G.
      • Lawrence V.A.
      • Cornell J.E.
      Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians.
      pulmonary risk stratification has only recently received attention.
      Postoperative pulmonary complications increase length of hospital stay, morbidity, and mortality,
      • Johnson R.G.
      • Arozullah A.M.
      • Neumayer L.
      • et al.
      Multivariable predictors of postoperative respiratory failure after general and vascular surgery: results from the Patient Safety in Surgery Study.
      and in the case of ambulatory surgery, unplanned admissions. In one study of morbidity and mortality within 1 month of ambulatory surgery, respiratory failure constituted 16% of all morbidity.
      • Warner M.A.
      • Shields S.E.
      • Chute C.G.
      Major morbidity and mortality within 1 month of ambulatory surgery and anesthesia.
      In a respiratory risk index developed for respiratory failure after vascular or general surgery, respiratory failure was defined as postoperative mechanical ventilation for longer than 48 hours or unanticipated reintubation. Twenty-eight variables were independently associated with respiratory failure, including alcohol use (>2 drinks per day for 2 weeks before the procedure), greater than 10% weight loss in the previous 6 months, elevated blood urea nitrogen levels, low albumin levels, smoking, general anesthesia, and a surgical time from 2.5 to 4 hours.
      • Johnson R.G.
      • Arozullah A.M.
      • Neumayer L.
      • et al.
      Multivariable predictors of postoperative respiratory failure after general and vascular surgery: results from the Patient Safety in Surgery Study.
      • Smetana G.W.
      • Conde M.
      Preoperative pulmonary update.
      The site and complexity of the operation are the most important factors for evaluating risk of respiratory failure. For procedures with relative value units (RVUs) from 10 to 17, such as orthopedic surgery, exploratory laparotomies, or hysterectomy, the OR for respiratory failure is 2.299 (confidence interval [CI], 1.937–2.728); for RVUs greater than 17 (eg, cardiac surgery, airway surgery, craniotomies), the OR is 4.445 (CI, 3.720–5.312). In other words, patients who undergo cardiac, thoracic, major vascular, or upper abdominal surgery, or head and neck procedures are at increased risk for postoperative respiratory failure.
      • Arozullah A.M.
      • Khuri S.F.
      • Henderson W.G.
      • et al.
      Development and validation of a multifactorial risk index for predicting postoperative pneumonia after major noncardiac surgery.
      COPD is the most frequently identified risk factor for postoperative pulmonary complications,
      • Smetana G.
      • Lawrence V.A.
      • Cornell J.E.
      Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians.
      • Smetana G.W.
      Preoperative pulmonary evaluation.
      such as atelectasis, pneumonia, respiratory failure, and exacerbation of underlying chronic lung disease. In an analysis of 15 studies, the OR was 1.79 (CI, 1.44–2.22) for pulmonary complications in patients with COPD.
      • Smetana G.
      • Lawrence V.A.
      • Cornell J.E.
      Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians.
      Another study calculated an OR of 1.517 (CI, 1.362–1.689) for respiratory complications in patients with COPD,
      • Johnson R.G.
      • Arozullah A.M.
      • Neumayer L.
      • et al.
      Multivariable predictors of postoperative respiratory failure after general and vascular surgery: results from the Patient Safety in Surgery Study.
      and a Canadian study showed that COPD increased operative events by a factor of 2.
      • Wong D.H.
      • Weber E.C.
      • Schell M.J.
      • et al.
      Factors associated with postoperative pulmonary complications in patients with severe chronic obstructive pulmonary disease.
      Patients are at highest risk in the immediate postoperative period from respiratory motor dysfunction, hypoxia, and hypoventilation,
      • Duncan P.G.
      • Cohen M.M.
      • Tweed W.A.
      • et al.
      The Canadian four-centre study of anaesthetic outcomes: III. Are anaesthetic complications predictable in day surgical practice?.
      and should be closely monitored. COPD in isolation is only a minor risk factor for postoperative respiratory failure.
      Whether spirometry or chest radiographs help with pulmonary risk stratification or provide incrementally more information than the history and physical examination has not been determined,
      • Smetana G.
      • Lawrence V.A.
      • Cornell J.E.
      Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians.
      • Smetana G.W.
      • Conde M.
      Preoperative pulmonary update.
      and these tests should not be performed routinely for preoperative assessment. Guidelines from the American College of Physicians recommend that patients with stable COPD, irrespective of forced expiratory volume in the first second of expiration (FEV1), be treated with inhaled bronchodilators. Patients with symptomatic COPD and an FEV1 less than 60% of predicted percentage should be treated with either a long-acting inhaled anticholinergic or a long-acting inhaled β-agonist
      • Qaseem A.
      • Wilt T.J.
      • Weinberger S.E.
      • et al.
      Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society.

      Standards of the diagnosis and management of patients with COPD. American Thoracic Society Web site. Available at: http://www.thoracic.org/clinical/copd-guidelines/index.php. Accessed September 8, 2012.

      and treatment should continue through the perioperative period. As for intraoperative management, a meta-analysis showed that spinal and epidural anesthetics decrease postoperative mortality, deep vein thrombosis, pneumonia, and respiratory depression.
      • Rodgers A.
      • Walker N.
      • Schug S.
      • et al.
      Reduction of postoperative mortality and morbidity with epidural or spinal anesthesia: results from overview of randomized trials.
      Even though the prevalence of asthma in the United States is increasing,
      • Chung F.
      • Mezei G.
      Factors contributing to a prolonged stay after ambulatory surgery.
      • Centers for Disease Control and Prevention (CDC)
      Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
      morbidity and mortality are decreasing because of advances in medical management.
      • Centers for Disease Control and Prevention (CDC)
      Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
      Patients with asthma have varying degrees of airway obstruction, inflammation, and hyperresponsiveness. During anesthesia, aspiration, infection, instrumentation of the airway, the administration of certain drugs, or an inadequate depth of anesthesia may induce bronchospasm,
      • Centers for Disease Control and Prevention (CDC)
      Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
      and patients with a history of asthma have a 5-fold risk of postoperative respiratory events.
      • Woods B.D.
      • Sladen R.N.
      Perioperative considerations for the patient with asthma and bronchospasm.
      Although perioperative bronchospasm is a concern, it occurs in only approximately 2% of patients.
      • Centers for Disease Control and Prevention (CDC)
      Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
      • Woods B.D.
      • Sladen R.N.
      Perioperative considerations for the patient with asthma and bronchospasm.
      As with patients with COPD, preoperative optimization is critical. Current guidelines indicate that inhaled corticosteroids are the most effective agents for long-term control of the disease.
      • National Institutes of Health
      • National Heart Lung and Blood Institute
      Expert panel report 3: guidelines for the diagnosis and management of asthma.
      Smoking cessation is a preoperative measure that can decrease the hyperreactivity of the airway, and not smoking for as few as 4 weeks preoperatively improves outcomes.
      • Smetana G.W.
      • Conde M.
      Preoperative pulmonary update.
      The American Thoracic Society and the European Respiratory Society recommend that patients cease smoking 6 to 8 weeks before surgery.
      • Centers for Disease Control and Prevention (CDC)
      Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
      Pulmonary risk factors alone do not predict postoperative pulmonary complications; the type of procedure and the surgical location are the most important predictors.
      • Smetana G.W.
      • Conde M.
      Preoperative pulmonary update.
      • Wong D.H.
      • Weber E.C.
      • Schell M.J.
      • et al.
      Factors associated with postoperative pulmonary complications in patients with severe chronic obstructive pulmonary disease.
      COPD is not an absolute contraindication to any surgery, but elective surgery should be postponed to treat an exacerbation of COPD or asthma. Well-controlled asthma does not increase risk for perioperative complications.
      • Centers for Disease Control and Prevention (CDC)
      Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
      • National Institutes of Health
      • National Heart Lung and Blood Institute
      Expert panel report 3: guidelines for the diagnosis and management of asthma.

      Elderly patients

      Currently in the United States, 39.6 million Americans are older than 65 years, and by 2030, the Census Bureau estimates the number will exceed 72.1 million.

      Older Americans 2012: Key Indicators of Well Being. Federal Interagency Forum on Aging Related Statistics. Available at: http://www.agingstats.gov/agingstatsdotnet/main_site/default.aspx. Accessed August 12, 2012.

      Elderly patients may benefit greatly from an ambulatory procedure because they will be discharged home the day of surgery and may experience less cognitive impairment.
      • Mattila K.
      • Vironen J.
      • Eklund A.
      • et al.
      Randomized clinical trial comparing ambulatory and inpatient care after inguinal hernia repair in patients aged 65 years or older.
      In addition to neurologic deterioration, aging causes physiologic changes in the body, including “vascular stiffening,” which elevates blood pressure and increases pulse pressure. Unlike diastolic blood pressure (DBP), systolic blood pressure (SBP) increases an average of 6.2 mm Hg per decade,
      • Chen C.H.
      • Nakayama M.
      • Nevo E.
      • et al.
      Coupled systolic-ventricular and vascular stiffening with age implications for pressure regulation and cardiac reserve in the elderly.
      and the prevalence of cardiovascular disease also increases with age.
      • Betelli G.
      Anaesthesia for the elderly outpatient: preoperative assessment and evaluation, anesthetic technique and postoperative pain management.
      In the lungs, elastic recoil diminishes, the chest wall stiffens, and motor power for respirations weakens in a smaller intervertebral space, all of which can promote atelectasis. Elderly people also have an impaired respiratory response to elevated carbon dioxide and hypoxia, making them more sensitive to the respiratory effects of narcotics and other anesthetic agents.
      • Wahba W.M.
      Influence of aging on lung function—clinical significance of changes from age twenty.
      • White P.F.
      • White L.M.
      • Monk T.
      • et al.
      Perioperative care for the older outpatient undergoing ambulatory surgery.
      Perioperative mortality increases with age, especially after emergency procedures or major surgery.
      • Jin F.
      • Chung F.
      Minimizing perioperative adverse events in the elderly.
      Elderly people are at greater risk for intraoperative events, such as hypertension, hypotension, and arrhythmia (OR, 1.42); intraoperative bleeding (OR, 1.31); and postoperative bruising (OR, 1.75),
      • Chung F.
      • Mezei G.
      • Tong D.
      Adverse events in ambulatory survey. A comparison between elderly and younger patients.
      • Chung F.
      • Mezei G.
      • Tong D.
      Pre-existing medical conditions as predictors of adverse events in day case surgery.
      • Cutter P.L.
      • Trinhaus K.M.
      Hemorrhagic complications of oculoplastic surgery.
      but their risk for postoperative pain (OR, 0.2), shivering, nausea and vomiting (OR, 0.3), and desaturation (OR, 0.4) is less.
      • Chung F.
      • Mezei G.
      • Tong D.
      Pre-existing medical conditions as predictors of adverse events in day case surgery.
      Patients older than 85 years with serious comorbidities are more likely to need hospital admission,
      • Fleisher L.A.
      • Pasternak L.R.
      • Herbert R.
      • et al.
      Inpatient hospital admission and death after outpatient surgery in elderly patients. Importance of patient and system characteristics and location of care.
      and elderly patients with a previous hospital admission within 6 months of the surgery have a 2-fold greater risk for unanticipated postoperative admission. Unanticipated hospital admissions rates after outpatient surgery remain at less than 3%.
      • Mattila K.
      • Vironen J.
      • Eklund A.
      • et al.
      Randomized clinical trial comparing ambulatory and inpatient care after inguinal hernia repair in patients aged 65 years or older.
      • Fleisher L.A.
      • Pasternak L.R.
      • Herbert R.
      • et al.
      Inpatient hospital admission and death after outpatient surgery in elderly patients. Importance of patient and system characteristics and location of care.
      Despite the risks, the overall mortality for elderly patients undergoing ambulatory procedures remains low. Of 564,267 outpatient surgical procedures in patients older than 65 years, the overall death rate per 100,000 was 2.3 on the day of the procedure, 5.1 on days 1 to 7 afterward, and 6.6 on days 8 to 30.
      • Fleisher L.A.
      • Pasternak L.R.
      • Herbert R.
      • et al.
      Inpatient hospital admission and death after outpatient surgery in elderly patients. Importance of patient and system characteristics and location of care.
      Despite physiologic changes in the elderly, ambulatory surgery has proven to be safe, which can be attributed to careful patient selection via a thorough preoperative assessment.
      • White P.F.
      • White L.M.
      • Monk T.
      • et al.
      Perioperative care for the older outpatient undergoing ambulatory surgery.
      To evaluate an elderly patient for ambulatory surgery, consideration is given to the type of surgery, the surgical and anesthetic risk, and the functional capacity of the patient. The medical condition of the patient is optimized before surgery to minimize risk and reduce the likelihood of adverse events.
      • Shnaider I.
      • Chung F.
      Outcomes in day surgery.
      • McGory M.L.
      • Kao K.K.
      • Shekelle P.G.
      • et al.
      Developing quality indicators for elderly surgical patients.
      • Jakobsson J.
      Ambulatory anaesthesia: there is room for further improvements of safety and quality of care—is the way forward further simply one of evidence-based risk scores?.
      As with all patients, the social situation should be evaluated to determine whether the elderly patient has help at home for postoperative care.
      • Mattila K.
      • Vironen J.
      • Eklund A.
      • et al.
      Randomized clinical trial comparing ambulatory and inpatient care after inguinal hernia repair in patients aged 65 years or older.

      Hypertension

      In the United States, 1 in 3 individuals has hypertension. Although men younger than 45 years have a higher prevalence, the percentages of men and women equalize thereafter.
      • Holmes J.S.
      • Kozak L.J.
      • Owings M.F.
      Use and in-hospital mortality associated with two cardiac procedures, by sex and age: National Trends, 1990-2003.
      In people older than 65 years, the prevalence increases to more than 50%.
      • Roger V.L.
      • Go A.S.
      • Lloyd-Jones D.M.
      • et al.
      Heart disease and stroke statistics—2012 update. A report from the American Heart Association.
      The diagnosis of hypertension requires, “the average of two or more properly measured, seated blood pressure readings on each of two or more office visits.”

      Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7 Express). Available at: http://www.nhlbi.nih.gov/guidelines/hypertension/jnc7full.pdf. Accessed November 25, 2012.

      Stage 1 hypertension is a SBP of 140 to 159 mm Hg or a DBP of 90 to 99 mm Hg. Stage 2 is an SBP greater than or equal to 160 mm Hg or DBP greater than or equal to 100 mm Hg.

      Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7 Express). Available at: http://www.nhlbi.nih.gov/guidelines/hypertension/jnc7full.pdf. Accessed November 25, 2012.

      Although not described in the updated National Institutes of Health model of 2007, the literature describes stage 3 of hypertension as an SBP greater than or equal to 180 mm Hg or DBP greater than or equal to 110 mm Hg.
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      Hypertension in outpatient surgery has not been extensively studied, and most of the outcome data have come from the studies conducted on inpatients. Beyer and colleagues
      • Beyer K.
      • Taffe P.
      • Halfon P.
      • et al.
      Hypertension and intra-operative incidents: a multicenter study of 125000 surgical procedures in Swiss Hospitals.
      evaluated 125,000 procedures over 5 years and found that patients with hypertension had a 40% increased risk of an intraoperative arrhythmia or hemodynamic abnormalities. Wax and colleagues
      • Wax D.B.
      • Porter S.B.
      • Lin H.M.
      • et al.
      Association of preanesthesia hypertension with adverse outcomes.
      found that increased levels of preinduction SBP and DBP were an independent risk factor for postoperative myocardial injury, infarction, or death. In the outpatient setting, Chung and colleagues
      • Chung F.
      • Mezei G.
      • Tong D.
      Pre-existing medical conditions as predictors of adverse events in day case surgery.
      found that hypertension was associated with increased intraoperative events, primarily cardiovascular, and included hypertension, arrhythmias, hypotension, tachycardia, and bradycardia. It was also associated with increased postoperative events, including hematoma. They recommend careful preoperative blood pressure control and perioperative management. This recommendation is consistent with the 2007 ACC/AHA guidelines that state if a patient presents for initial evaluation with stage 1 or 2 hypertension and has no end-organ disease or associated metabolic abnormalities, there is no reason to delay surgery. The meta-analysis by Howell and colleagues
      • Howell S.J.
      • Sear J.W.
      • Foex P.
      Hypertension, hypertensive heart disease and perioperative cardiac Risk.
      further supports the ACC/AHA recommendation, which found insufficient evidence of an association between SBP less than 180 mm Hg and DBP less than 100 mm Hg and perioperative complications. However, the ACC/AHA guidelines recommend that elective surgery be postponed for patients with stage 3 hypertension to improve blood pressure control over several days or even weeks.
      • Fleisher L.A.
      • Beckman J.A.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
      Although the literature does not have any consensus about delaying or canceling surgery for stage 3 hypertension, it does suggest that hypertension should not be looked at in isolation when determining whether to proceed, and that it need not be regarded as an absolute contraindication. For patients with end-organ damage induced by hypertension (eg, ischemic heart disease, heart failure, renal or cerebrovascular disease) whose perioperative risk would be substantially decreased by delaying the procedure, hypertension management should be considered. In addition, the urgency or necessity of the procedure should be taken into consideration.
      • Hanada S.
      • Kawakami H.
      • Goto T.
      • et al.
      Hypertension and anesthesia.

      Obstructive sleep apnea

      Approximately 2% to 25% of the general population has obstructive sleep apnea (OSA)
      • Young T.
      • Hutton R.
      • Finn L.
      • et al.
      The gender bias in sleep apnea diagnosis. Are women missed because they have different symptoms?.
      and may have other comorbidities, such as hypertension and obesity.
      • Liao P.
      • Yegneswaran B.
      • Vairavanthan S.
      • et al.
      Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study.
      Because of a concern for possible perioperative complications, a question exists about the appropriateness of allowing patients with OSA to undergo ambulatory surgery.
      Individuals with OSA have physical alterations of the lateral pharyngeal walls and tongue. Their computed tomography and magnetic resonance imaging studies reveal fat deposits and submucosal edema, which narrow the pharyngeal airway.
      • Patil S.P.
      • Schneider H.
      • Schwartz A.R.
      Adult obstructive sleep apnea pathophysiology and diagnosis.
      During awake respiration, activity of the upper airway dilator muscle counteracts the effect of a narrowed airway,
      • Patil S.P.
      • Schneider H.
      • Schwartz A.R.
      Adult obstructive sleep apnea pathophysiology and diagnosis.
      but inhaled anesthetics and narcotics collapse the airway. Narcotics can exacerbate the problem through inducing central apnea.
      • Waters K.A.
      • McBrien F.
      • Stewart P.
      • et al.
      Effects of OSA, inhalational anesthesia and fentanyl on the airway and ventilation of children.
      OSA is an independent risk factor for morbidity and mortality.
      • Sabers C.
      • Plevak D.J.
      • Schroeder D.R.
      • et al.
      The diagnosis of obstructive sleep apnea as a risk factor for unanticipated admissions in outpatient surgery.
      Among postoperative complications of patients with OSA, oxygen desaturation is the most common
      • Liao P.
      • Yegneswaran B.
      • Vairavanthan S.
      • et al.
      Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study.
      and more likely to occur immediately after extubation than later in the postanesthesia care unit.
      • Liu S.S.
      • Chisholm M.F.
      • John R.S.
      • et al.
      Risk of postoperative hypoxemia in ambulatory orthopedic surgery patients with diagnosis of obstructive sleep apnea: a retrospective observational study.
      Postoperative hypoxia does not seem to result in increased mortality, unanticipated hospital admission, or delay in discharge.
      • Sabers C.
      • Plevak D.J.
      • Schroeder D.R.
      • et al.
      The diagnosis of obstructive sleep apnea as a risk factor for unanticipated admissions in outpatient surgery.
      • Joshi G.P.
      • Ankichetty S.P.
      • Gan T.J.
      • et al.
      Society for Ambulatory Anesthesia consensus statement on preoperative selection of adult patients with obstructive sleep apnea scheduled for ambulatory surgery.
      • Kurrek M.M.
      • Cobourn C.
      • Wojtasik Z.
      • et al.
      Morbidity in patients with or high risk for obstructive sleep apnea after ambulatory laparoscopic gastric banding.
      A meta-analysis by the Society of Ambulatory Anesthesia (SAMBA) found no increase in mortality and no correlation between adverse events and clinically significant adverse outcomes. Despite postoperative hypoxemia, no intubation or ventilator assistance was required.
      • Joshi G.P.
      • Ankichetty S.P.
      • Gan T.J.
      • et al.
      Society for Ambulatory Anesthesia consensus statement on preoperative selection of adult patients with obstructive sleep apnea scheduled for ambulatory surgery.
      In a consensus statement on preoperative selection of patients with OSA scheduled for ambulatory surgery, SAMBA recommended screening patients with the STOP BANG questionnaire because it is simple to administer (Box 2) and accurately predicts the probability that a patient has moderate to severe OSA. A STOP BANG score of 5 had an OR of 4.5 for moderate/severe OSA and an OR of 10.4 for severe OSA. A score of 7 to 8 had an OR of 6.9 for moderate/severe OSA and an OR of 14.9 for severe OSA.
      • Chung F.
      • Subramanyam R.
      • Liao P.
      • et al.
      High STOP-Bang score indicates a high probability of obstructive sleep apnoea.
      Fig. 2 presents a decision-making algorithm for preoperative selection.
      The STOP BANG questionnaire
      • S = Snoring: do you snore loudly (louder than talking or loud enough to be heard through closed doors)?
      • T = Tiredness: do you often feel tired fatigued, or sleepy during daytime?
      • O = Observed apnea: has anyone ever observed you stop breathing during your sleep?
      • P = Pressure: do you have or are you being treated for high blood pressure?
      • B = BMI >35 kg/m2
      • A = Age >50 years
      • N = Neck circumference >40 cm
      • G = Gender male
      Low risk for OSA: <3 questions positive.
      High risk of OSA: ≥3 questions positive.
      High probability of moderate to severe OSA: 5–8 questions positive.
      Figure thumbnail gr2
      Fig. 2Decision-making algorithm for patients with OSA.

      Diabetes mellitus

      In the United States, 8.3% of the population has been diagnosed with diabetes, with approximately 1.9 million new diagnoses every year.

      Diabetes statistics. American Diabetes Association Web site. Available at: http://www.diabetes.org/diabetes-basics/diabetes-statistics/. Accessed October 5, 2012.

      Because people with diabetes require more surgical procedures than those without,
      • Dagogo-Jack S.
      • Alberti K.
      Management of diabetes mellitus in surgical patients.
      they are often cared for in an ambulatory surgery center. Many of the recommendations for glucose management in patients with diabetes undergoing ambulatory surgery have been extrapolated from studies of inpatient surgeries.
      • Joshi G.P.
      • Chung F.
      • Vann M.A.
      • et al.
      Society for Ambulatory Anesthesia consensus statement on perioperative blood glucose management in diabetic patients undergoing ambulatory surgery.
      A hyperglycemic condition can cause metabolic derangements, including dehydration, electrolyte abnormalities, and ketoacidosis.
      • Akhtar S.
      • Barash P.G.
      • Inzucchi S.E.
      Scientific principles and clinical implications of perioperative glucose regulation and control.
      The stress response of surgery triggers the release of epinephrine, norepinephrine, cortisol, glucagon, and growth hormones.
      • Dagogo-Jack S.
      • Alberti K.
      Management of diabetes mellitus in surgical patients.
      • Sheehy A.M.
      • Gabbay R.A.
      An overview of preoperative glucose evaluation, management and perioperative impact.
      These catabolic hormones combine with the inhibited insulin secretion that results from the stress response to raise blood glucose levels in the perioperative period.
      • Dagogo-Jack S.
      • Alberti K.
      Management of diabetes mellitus in surgical patients.
      • Sheehy A.M.
      • Gabbay R.A.
      An overview of preoperative glucose evaluation, management and perioperative impact.
      As with inpatients, the main objective in management is to preserve glucose control and prevent hypoglycemia.
      • Sheehy A.M.
      • Gabbay R.A.
      An overview of preoperative glucose evaluation, management and perioperative impact.
      Pharmacologic treatment of patients with diabetes includes oral hypoglycemic medications, long- or short-acting insulin, or a combination of the aforementioned agents. Patients taking oral hypoglycemic medications should be instructed to take their medications as they normally would on the day before surgery, but these agents should be discontinued on the day of surgery. Patients taking long-acting or intermediate-acting insulin take their prescribed doses while eating a normal diet.
      • Vann M.A.
      Perioperative management of ambulatory surgical patients with diabetes mellitus.
      On the day of surgery, patients who take intermediate-acting agents (eg, neutral protamine Hagedorn insulin [NPH], Lente) may need to decrease or discontinue the dose, because they may experience hypoglycemia if a meal is omitted.
      • Joshi G.P.
      • Chung F.
      • Vann M.A.
      • et al.
      Society for Ambulatory Anesthesia consensus statement on perioperative blood glucose management in diabetic patients undergoing ambulatory surgery.
      Patients taking long-acting insulin agents reduce the dose on the day of surgery.
      On the day of surgery, blood glucose should minimally be measured on the patient’s arrival at the surgical facility and postoperatively. If the surgical procedure is prolonged, blood glucose levels should be checked intraoperatively.
      • Dagogo-Jack S.
      • Alberti K.
      Management of diabetes mellitus in surgical patients.
      Consensus has not been reached on an optimal intraoperative blood glucose level, but the NICE-SUGAR study found that patients with a blood glucose level less than 180 mg/dL had a lower mortality rate than those whose glucose level was tightly controlled between 81 and 108 mg/dL.
      • The NICE-SUGAR Study Investigators
      Intensive versus conventional glucose control in critically ill patients.
      Diabetes in and of itself is not a contraindication to ambulatory surgery, but patients with diabetes often have other comorbidities, such as hypertension, dyslipidemia, obesity, and chronic kidney disease. The evaluation of a patient’s medical status determines whether an ambulatory setting is appropriate for the procedure. If a surgical facility is going to care for patients with diabetes, it must have the necessary equipment to test and monitor blood glucose levels.

      Obesity

      Obesity is defined as a body mass index (BMI) greater than 30 kg/m2; morbid obesity is a BMI greater than 40 kg/m2.
      • Cullen A.
      • Ferguson A.
      Perioperative management of the severely obese patient: a selective pathophysiological review.
      The CDC reports that by the year 2030, 42% of Americans will be obese. The CDC also predicts that in 2030 the severely obese will constitute 11% of the population.
      • Ogden C.L.
      • Carroll M.D.
      • Kit B.K.
      • et al.
      Prevalence of obesity in the United States, 2009-2010.
      Obese patients are likely to have hypertension, coronary artery disease, OSA, asthma, diabetes, and metabolic syndrome. Obesity alone is not a risk factor for unanticipated admissions after ambulatory surgery,
      • Hofer R.E.
      • Kai T.
      • Decker P.
      • et al.
      Obesity as a risk factor for unanticipated admissions after ambulatory surgery.
      but obese patients have a statistically significant higher incidence of intraoperative bronchospasm than nonobese patients and require supplemental oxygen postoperatively.
      • Hofer R.E.
      • Kai T.
      • Decker P.
      • et al.
      Obesity as a risk factor for unanticipated admissions after ambulatory surgery.
      The patient’s comorbidities, the anesthetic required, and the type of surgery determine whether a patient is a candidate for a procedure in an ambulatory setting.

      Preoperative testing

      Screening laboratory tests have not been shown to be useful and are likely a waste of resources. Preoperative tests for screening purposes tend to be nonspecific and do not change the anesthetic management of the patient in the ambulatory setting.
      • Richman D.C.
      Ambulatory surgery: how much testing do we need?.
      Studies have has also demonstrated that eliminating routine testing does not increase risk.
      • Schein O.D.
      • Katz J.
      • Bass E.B.
      • et al.
      The value of routine preoperative medical testing before cataract surgery. Study of Medical Testing for Cataract Surgery.
      A study of 1061 patients randomized to undergo either directed preoperative testing or no preoperative testing showed no significant difference in rates of adverse events between ambulatory surgical groups. The authors concluded that testing may be safely eliminated in selected patients.
      • Chung F.
      • Yuan H.
      • Yin L.
      • et al.
      Elimination of preoperative testing in ambulatory surgery.
      • Fleisher L.A.
      • Bechman A.J.
      • Brown K.A.
      • et al.
      ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery.

      Summary

      Ambulatory surgery is commonplace for a multitude of procedures and a wide range of patients. The types of procedures performed in the ambulatory setting are becoming more work-intensive, and patients with comorbidities make for a challenging environment. For a safe environment for surgery in ambulatory facilities, the complex task of patient selection is necessary. Until an algorithm is created that includes provider, procedure, facility, and patient comorbidites, clinicians must rely on general guidelines rather than precise recommendations. When determining whether a patient is suitable for ambulatory surgery, multiple factors must be assessed. The surgical procedure, who will be performing the surgical procedures, whether anesthesia is required, the type of anesthesia provider (eg, conscious sedation with a surgeon and nurse, an anesthesiologist, or a CRNA), and the surgical setting (eg, hospital-based ambulatory surgical center vs free-standing surgical center vs a physician’s office) all must be taken into account. In addition to these factors, patients and their comorbidities must be considered. Individual medical problems (eg, coronary artery disease, COPD, diabetes) taken in isolation often are not absolute contraindications to ambulatory surgery; patients must be evaluated as a whole to determine whether the procedure can be performed on an ambulatory basis.

      References

      1. MEDPAC Report to the Congress: Medicare Payment Policy. 2004.

        • Cullen K.A.
        • Hall M.J.
        • Golosinskiy A.
        Ambulatory surgery in the United States, 2006.
        Natl Health Stat Report. 2009; 11: 1-28
      2. Guidelines for ambulatory anesthesia and surgery. American Society of Anesthesiologists Web site. Available at: http://www.asahq.org/For-Healthcare-Professionals/Standards-Guidelines-and-Statements.aspx. Accessed August 31, 2012.

      3. Evidence-based patient safety advisory: patient selection and procedures in ambulatory surgery. Agency for Healthcare Research and Quality Web site. Available at: http://guidelines.gov/content.aspx?id=15334. Accessed September 1, 2012.

      4. Standards for basic anesthetic monitoring. American Society of Anesthesiologists Web site. Available at: http://www.asahq.org/For-Healthcare-Professionals/Standards-Guidelines-and-Statements.aspx. Accessed September 10, 2012.

        • Memtsoudis S.G.
        • Ma Y.
        • Swamidoss C.P.
        • et al.
        Factors influencing unexpected disposition after orthopedic ambulatory surgery.
        J Clin Anesth. 2012; 24: 89-95
        • White P.F.
        Outpatient anesthesia.
        Churchill Livingstone, New York1990 (p. 2–5)
        • Schwam S.J.
        • Gold M.I.
        • Craythorne N.W.
        The ASA physical status classification: a revision.
        Anesthesiology. 1962; 577: A439
        • Voney G.
        • Biro P.
        • Roos M.
        • et al.
        Interrelation of peri-operative morbidity and ASA class assignment in patients undergoing gynaecological surgery.
        Eur J Obstet Gynecol Reprod Biol. 2007; 132: 220-225
        • Davenport D.L.
        • Bowe E.A.
        • Henderson W.G.
        • et al.
        National Surgical Quality Improvement Program (NSQIP) risk factors can be used to validate American Society of Anesthesiologists Physical Status Classification (ASA PS) levels.
        Ann Surg. 2006; 243: 636-644
        • Warner M.A.
        • Shields S.E.
        • Chute C.G.
        Major morbidity and mortality within 1 month of ambulatory surgery and anesthesia.
        JAMA. 1993; 270: 1437-1441
        • Fortier J.
        • Chung F.
        • Su J.
        Unanticipated admission after ambulatory surgery—a prospective study.
        Can J Anaesth. 1998; 45: 612-619
        • Ansell G.L.
        • Montgomery J.E.
        Outcome of ASA III patients undergoing day case surgery.
        Br J Anaesth. 2004; 92: 71-74
        • Verma R.
        • Alladi R.
        • Jackson I.
        • et al.
        Guidelines: day case and short stay surgery: 2.
        Anaesthesia. 2011; 66: 417-434
        • Centers for Disease Control and Prevention (CDC)
        Prevalence of coronary heart disease—United States 2006-2010.
        MMWR Morb Mortal Wkly Rep. 2011; 60: 1377-1381
        • Xu J.Q.
        • Kochanek K.D.
        • Murphy S.L.
        • et al.
        Deaths: final data for 2007.
        Natl Vital Stat Rep. 2010; 58: 1-135
        • Fleisher L.A.
        • Beckman J.A.
        • Brown K.A.
        • et al.
        ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery).
        J Am Coll Cardiol. 2007; 50: e159-e241
        • Goldman L.
        • Claldera D.L.
        • Soutwick F.S.
        • et al.
        Cardiac risk factors and complications in non-cardiac surgery.
        Medicine. 1978; 57: 357-370
        • Larsen K.D.
        • Rubinfeld I.S.
        Changing risk of perioperative myocardial infarction.
        Perm J. 2012; 16: 4-9
        • Sweitzer B.J.
        Preoperative screening, evaluation, and optimization of the patient’s medical status before outpatient surgery.
        Curr Opin Anaesthesiol. 2008; 21: 711-718
        • Reilly D.F.
        • McNeely M.J.
        • Doerner D.
        • et al.
        Self –reported exercise tolerance and the risk of serious perioperative complications.
        Arch Intern Med. 1999; 159: 2185-2192
        • Grines C.L.
        • Bonow R.O.
        • Case D.E.
        • et al.
        Antiplatelet therapy in patients with coronary artery stents. A science advisory from the American Heart Association, the American College of Cardiology, Society for Cardiovascular Angiography and Interventions, American College of Surgeons, and American Dental Association, with representation from the American College of Physicians.
        J Am Coll Cardiol. 2007; 49: 734-739
        • Iakovou I.
        • Schmidt T.
        • Bonizzoni E.
        • et al.
        Incidence, predictors and outcome of thrombosis after successful implantation of drug-eluting stents.
        JAMA. 2005; 293: 2126-2130
        • Akinbami L.
        • Moorman J.E.
        • Liu X.
        Asthma prevalence, health care use, and mortality: United States, 2005-2009.
        Natl Health Stat Report. 2011; : 1-14
        • Mannino D.M.
        • Homa D.M.
        • Akinbami L.J.
        • et al.
        Chronic obstructive pulmonary disease surveillance–United States, 1971-2000.
        MMWR Surveill Summ. 2001; 51: 1-16
        • Smetana G.
        • Lawrence V.A.
        • Cornell J.E.
        Preoperative pulmonary risk stratification for noncardiothoracic surgery: systematic review for the American College of Physicians.
        Ann Intern Med. 2006; 144: 581-595
        • Johnson R.G.
        • Arozullah A.M.
        • Neumayer L.
        • et al.
        Multivariable predictors of postoperative respiratory failure after general and vascular surgery: results from the Patient Safety in Surgery Study.
        J Am Coll Surg. 2007; 204: 1188-1198
        • Smetana G.W.
        • Conde M.
        Preoperative pulmonary update.
        Clin Geriatr Med. 2008; 24: 607-624
        • Arozullah A.M.
        • Khuri S.F.
        • Henderson W.G.
        • et al.
        Development and validation of a multifactorial risk index for predicting postoperative pneumonia after major noncardiac surgery.
        Ann Intern Med. 2001; 135: 846-857
        • Smetana G.W.
        Preoperative pulmonary evaluation.
        N Engl J Med. 1999; 340: 937-944
        • Wong D.H.
        • Weber E.C.
        • Schell M.J.
        • et al.
        Factors associated with postoperative pulmonary complications in patients with severe chronic obstructive pulmonary disease.
        Anesth Analg. 1995; 80: 276-284
        • Duncan P.G.
        • Cohen M.M.
        • Tweed W.A.
        • et al.
        The Canadian four-centre study of anaesthetic outcomes: III. Are anaesthetic complications predictable in day surgical practice?.
        Can J Anaesth. 1992; 39: 440-448
        • Qaseem A.
        • Wilt T.J.
        • Weinberger S.E.
        • et al.
        Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society.
        Ann Intern Med. 2011; 155: 181-191
      5. Standards of the diagnosis and management of patients with COPD. American Thoracic Society Web site. Available at: http://www.thoracic.org/clinical/copd-guidelines/index.php. Accessed September 8, 2012.

        • Rodgers A.
        • Walker N.
        • Schug S.
        • et al.
        Reduction of postoperative mortality and morbidity with epidural or spinal anesthesia: results from overview of randomized trials.
        BMJ. 2000; 321: 1493-1497
        • Chung F.
        • Mezei G.
        Factors contributing to a prolonged stay after ambulatory surgery.
        Anesth Analg. 1999; 89: 1352-1359
        • Centers for Disease Control and Prevention (CDC)
        Vital signs: asthma prevalence, disease characteristics, and self-management education—United States, 2001-2009.
        MMWR Morb Mortal Wkly Rep. 2011; 60: 547-552
        • Woods B.D.
        • Sladen R.N.
        Perioperative considerations for the patient with asthma and bronchospasm.
        Br J Anaesth. 2009; 103: i57-i65
        • National Institutes of Health
        • National Heart Lung and Blood Institute
        Expert panel report 3: guidelines for the diagnosis and management of asthma.
        US Department of Health and Human Services. National Institutes of Health, National Heart, Lung, and Blood Institute, Bethesda (MD)2007 (Available at:) (Accessed September 9, 2012)
      6. Older Americans 2012: Key Indicators of Well Being. Federal Interagency Forum on Aging Related Statistics. Available at: http://www.agingstats.gov/agingstatsdotnet/main_site/default.aspx. Accessed August 12, 2012.

        • Mattila K.
        • Vironen J.
        • Eklund A.
        • et al.
        Randomized clinical trial comparing ambulatory and inpatient care after inguinal hernia repair in patients aged 65 years or older.
        Am J Surg. 2011; 201: 179-185
        • Chen C.H.
        • Nakayama M.
        • Nevo E.
        • et al.
        Coupled systolic-ventricular and vascular stiffening with age implications for pressure regulation and cardiac reserve in the elderly.
        J Am Coll Cardiol. 1998; 32: 1221-1227
        • Betelli G.
        Anaesthesia for the elderly outpatient: preoperative assessment and evaluation, anesthetic technique and postoperative pain management.
        Curr Opin Anaesthesiol. 2010; 23: 726-731
        • Wahba W.M.
        Influence of aging on lung function—clinical significance of changes from age twenty.
        Anesth Analg. 1983; 62: 764-776
        • White P.F.
        • White L.M.
        • Monk T.
        • et al.
        Perioperative care for the older outpatient undergoing ambulatory surgery.
        Anesth Analg. 2012; 114: 1190-1215
        • Jin F.
        • Chung F.
        Minimizing perioperative adverse events in the elderly.
        Br J Anaesth. 2001; 87: 608-624
        • Chung F.
        • Mezei G.
        • Tong D.
        Adverse events in ambulatory survey. A comparison between elderly and younger patients.
        Can J Anaesth. 1999; 46: 309-321
        • Chung F.
        • Mezei G.
        • Tong D.
        Pre-existing medical conditions as predictors of adverse events in day case surgery.
        Br J Anaesth. 1999; 83: 262-270
        • Cutter P.L.
        • Trinhaus K.M.
        Hemorrhagic complications of oculoplastic surgery.
        Ophthal Plast Reconstr Surg. 2002; 18: 409-415
        • Fleisher L.A.
        • Pasternak L.R.
        • Herbert R.
        • et al.
        Inpatient hospital admission and death after outpatient surgery in elderly patients. Importance of patient and system characteristics and location of care.
        Arch Surg. 2004; 139: 67-72
        • Shnaider I.
        • Chung F.
        Outcomes in day surgery.
        Curr Opin Anaesthesiol. 2006; 19: 622-629
        • McGory M.L.
        • Kao K.K.
        • Shekelle P.G.
        • et al.
        Developing quality indicators for elderly surgical patients.
        Ann Surg. 2009; 260: 338-347
        • Jakobsson J.
        Ambulatory anaesthesia: there is room for further improvements of safety and quality of care—is the way forward further simply one of evidence-based risk scores?.
        Curr Opin Anaesthesiol. 2010; 23: 670-681
        • Holmes J.S.
        • Kozak L.J.
        • Owings M.F.
        Use and in-hospital mortality associated with two cardiac procedures, by sex and age: National Trends, 1990-2003.
        Health Aff. 2007; 26: 169-177
        • Roger V.L.
        • Go A.S.
        • Lloyd-Jones D.M.
        • et al.
        Heart disease and stroke statistics—2012 update. A report from the American Heart Association.
        Circulation. 2012; 125: e2-e220
      7. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7 Express). Available at: http://www.nhlbi.nih.gov/guidelines/hypertension/jnc7full.pdf. Accessed November 25, 2012.

        • Beyer K.
        • Taffe P.
        • Halfon P.
        • et al.
        Hypertension and intra-operative incidents: a multicenter study of 125000 surgical procedures in Swiss Hospitals.
        Anaesthesia. 2009; 64: 494-502
        • Wax D.B.
        • Porter S.B.
        • Lin H.M.
        • et al.
        Association of preanesthesia hypertension with adverse outcomes.
        J Cardiothorac Vasc Anesth. 2010; 24: 927-930
        • Howell S.J.
        • Sear J.W.
        • Foex P.
        Hypertension, hypertensive heart disease and perioperative cardiac Risk.
        Br J Anaesth. 2004; 92: 570-583
        • Hanada S.
        • Kawakami H.
        • Goto T.
        • et al.
        Hypertension and anesthesia.
        Curr Opin Anaesthesiol. 2006; 19: 315-319
        • Young T.
        • Hutton R.
        • Finn L.
        • et al.
        The gender bias in sleep apnea diagnosis. Are women missed because they have different symptoms?.
        Arch Intern Med. 1996; 156: 2445-2451
        • Liao P.
        • Yegneswaran B.
        • Vairavanthan S.
        • et al.
        Postoperative complications in patients with obstructive sleep apnea: a retrospective matched cohort study.
        Can J Anaesth. 2009; 56: 819-828
        • Patil S.P.
        • Schneider H.
        • Schwartz A.R.
        Adult obstructive sleep apnea pathophysiology and diagnosis.
        Chest. 2007; 132: 325-337
        • Waters K.A.
        • McBrien F.
        • Stewart P.
        • et al.
        Effects of OSA, inhalational anesthesia and fentanyl on the airway and ventilation of children.
        J Appl Physiol. 2002; 92: 1986-1994
        • Sabers C.
        • Plevak D.J.
        • Schroeder D.R.
        • et al.
        The diagnosis of obstructive sleep apnea as a risk factor for unanticipated admissions in outpatient surgery.
        Anesth Analg. 2003; 96: 1328-1335
        • Liu S.S.
        • Chisholm M.F.
        • John R.S.
        • et al.
        Risk of postoperative hypoxemia in ambulatory orthopedic surgery patients with diagnosis of obstructive sleep apnea: a retrospective observational study.
        Patient Saf Surg. 2010; 4: 9-13
        • Joshi G.P.
        • Ankichetty S.P.
        • Gan T.J.
        • et al.
        Society for Ambulatory Anesthesia consensus statement on preoperative selection of adult patients with obstructive sleep apnea scheduled for ambulatory surgery.
        Anesth Analg. 2012; 115: 1060-1068
        • Kurrek M.M.
        • Cobourn C.
        • Wojtasik Z.
        • et al.
        Morbidity in patients with or high risk for obstructive sleep apnea after ambulatory laparoscopic gastric banding.
        Obes Surg. 2011; 21: 1494-1498
        • Chung F.
        • Subramanyam R.
        • Liao P.
        • et al.
        High STOP-Bang score indicates a high probability of obstructive sleep apnoea.
        Br J Anaesth. 2012; 108: 768-775
      8. Diabetes statistics. American Diabetes Association Web site. Available at: http://www.diabetes.org/diabetes-basics/diabetes-statistics/. Accessed October 5, 2012.

        • Dagogo-Jack S.
        • Alberti K.
        Management of diabetes mellitus in surgical patients.
        Diabetes Spectr. 2002; 15: 44-48
        • Joshi G.P.
        • Chung F.
        • Vann M.A.
        • et al.
        Society for Ambulatory Anesthesia consensus statement on perioperative blood glucose management in diabetic patients undergoing ambulatory surgery.
        Anesth Analg. 2010; 111: 1378-1387
        • Akhtar S.
        • Barash P.G.
        • Inzucchi S.E.
        Scientific principles and clinical implications of perioperative glucose regulation and control.
        Anesth Analg. 2010; 110: 478-497
        • Sheehy A.M.
        • Gabbay R.A.
        An overview of preoperative glucose evaluation, management and perioperative impact.
        J Diabetes Sci Technol. 2009; 3: 1262-1269
        • Vann M.A.
        Perioperative management of ambulatory surgical patients with diabetes mellitus.
        Curr Opin Anaesthesiol. 2009; 22: 718-724
        • The NICE-SUGAR Study Investigators
        Intensive versus conventional glucose control in critically ill patients.
        N Engl J Med. 2009; 360: 1283-1297
        • Cullen A.
        • Ferguson A.
        Perioperative management of the severely obese patient: a selective pathophysiological review.
        Can J Anaesth. 2012; 59: 974-996
        • Ogden C.L.
        • Carroll M.D.
        • Kit B.K.
        • et al.
        Prevalence of obesity in the United States, 2009-2010.
        NCHS Data Brief. 2012; 82: 1-8
        • Hofer R.E.
        • Kai T.
        • Decker P.
        • et al.
        Obesity as a risk factor for unanticipated admissions after ambulatory surgery.
        Mayo Clin Proc. 2008; 83: 908-913
        • Richman D.C.
        Ambulatory surgery: how much testing do we need?.
        Anesthesiol Clin. 2010; 28: 185-197
        • Schein O.D.
        • Katz J.
        • Bass E.B.
        • et al.
        The value of routine preoperative medical testing before cataract surgery. Study of Medical Testing for Cataract Surgery.
        N Engl J Med. 2000; 342: 168-175
        • Chung F.
        • Yuan H.
        • Yin L.
        • et al.
        Elimination of preoperative testing in ambulatory surgery.
        Anesth Analg. 2009; 108: 467-475
        • Fleisher L.A.
        • Bechman A.J.
        • Brown K.A.
        • et al.
        ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery.
        Circulation. 2007; 116: e418-500